MAdCAM-1, chemokines, and cytokines in PP were measured by ELISA after LTR stimulation or blockade. PN decreases LTR, MAdCAM-1, and chemokines in PP and lowers small intestinal IgA compared with chow.Ĭanonical (p50 and p65) and noncanonical (p52 and Rel B) NF-B proteins in PP were analyzed by TransAM NF-B kit after 5 days of chow or PN, 2 days of LTR stimulation or 3 days of LTR blockade. TNF, IL-1, and bacterial products stimulate the inflammatory canonical NF-B pathway producing p65p50 and c-Relp50. The p100RelB precursor yields p52RelB producing MAdCAM-1, cytokines, and chemokines important in cell trafficking. LT stimulates LTR in Peyers patches (PP) to activate NF-B via the noncanonical pathway. Request full-text Download citation Copy link Link copied Request full-text Download citation Copy link Link copied To read the full-text of this research, you can request a copy directly from the authors.
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